Evidence for a direct inhibitory effect of glucocorticoids on the activity of phospholipase A2 as a further possible mechanism of some actions of steroidal anti-inflammatory drugs
| Autor: | P. Mentz, W. Förster, Ch. Gießler |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Administration Topical Anti-Inflammatory Agents Phospholipase Pharmacology Anti-inflammatory Dexamethasone Phospholipases A chemistry.chemical_compound Phospholipase A2 Internal medicine medicine Inhibitory effect Aldosterone Glucocorticoids Phospholipase A biology Dose-Response Relationship Drug Chemistry Phospholipases A2 Endocrinology Phospholipases biology.protein Prostaglandins Glucocorticoid medicine.drug |
| Zdroj: | Pharmacological research communications. 12(8) |
| ISSN: | 0031-6989 |
| Popis: | Summary Investigations on the influence of dexamethasone and aldosterone on the activity of phospholipase A 2 in a cell free medium indicated a dose — dependent inhibition by the glucocorticoid dexamethasone whereas aldosterone remained ineffective. The results showed a correlation between this effect and the anti-inflammatory action of dexamethasone possibly due to an inhibition of prostaglandin biosynthesis. Moreover prostaglandins also suppress the activity of phospholipases, regulating their own formation in this way. |
| Databáze: | OpenAIRE |
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