Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension
| Autor: | Renske Uiterwijk, Robert J. van Oostenbrugge, Marjolein Huijts, Sander M. J. van Kuijk, Peter W. de Leeuw, Abraham A. Kroon, Julie Staals |
|---|---|
| Přispěvatelé: | RS: MHeNs - R2 - Mental Health, Promovendi MHN, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: CARIM - R3.03 - Cerebral small vessel disease, MUMC+: MA Niet Med Staf Psychologie (9), RS: CAPHRI - R2 - Creating Value-Based Health Care, MUMC+: KIO Kemta (9), Interne Geneeskunde, RS: CARIM - R3.02 - Hypertension and target organ damage, MUMC+: MA Alg Interne Geneeskunde (9), MUMC+: MA Neurologie (3), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience |
| Rok vydání: | 2018 |
| Předmět: |
Male
cognition MICROBLEEDS Endocrinology Diabetes and Metabolism renal damage BLOOD-PRESSURE Neuropsychological Tests 030204 cardiovascular system & hematology Kidney Essential hypertension 0302 clinical medicine Cost of Illness Neuropsychological assessment Stroke Netherlands RISK medicine.diagnostic_test cerebral small vessel disease DEMENTIA Brain Heart WHITE-MATTER LESIONS Middle Aged Magnetic Resonance Imaging Echocardiography Doppler 3. Good health Cognitive Function Cardiology Female Hypertrophy Left Ventricular medicine.symptom Cardiology and Cardiovascular Medicine STROKE Glomerular Filtration Rate medicine.medical_specialty hypertension Brain damage SMALL-VESSEL DISEASE 03 medical and health sciences Predictive Value of Tests Internal medicine Internal Medicine medicine Albuminuria Humans Dementia Cognitive Dysfunction DECLINE Original Paper business.industry medicine.disease DYSFUNCTION Hyperintensity HYPERTROPHY Blood pressure Cerebral Small Vessel Diseases cardiac damage business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | The Journal of Clinical Hypertension Journal of Clinical Hypertension (Greenwich, Conn.) Journal of Clinical Hypertension, 20(10), 1458-1463. Wiley |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/jch.13372 |
| Popis: | Hypertension is associated with cognitive deficits, probably caused by cerebral small vessel disease. The authors examined whether additional presence of cardiac and renal organ damages, and their combined presence, are associated with future cognitive performance. In 78 patients with essential hypertension (mean age 51.2 +/- 12.0 years), brain damage was determined by MRI features, cardiac damage by left ventricular mass index (LVMI), and renal damage by estimated glomerular filtration rate (eGFR) and albuminuria. At 9-year follow-up, neuropsychological assessment was performed. LVMI was associated with future lower cognition (P = 0.032), independent of age, sex, premorbid cognition, and brain damage, but eGFR and albuminuria were not. The presence of 2 or 3 types of organ damage compared to none was associated with future lower cognition. Increasing number of hypertensive organ damages, and cardiac damage independently of brain damage, might indicate a more severe hypertensive disease burden and could help to identify patients at risk of cognitive problems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|