Virus–host interplay in hepatitis B virus infection and epigenetic treatment strategies
| Autor: | Kai O. Hensel, Jan Postberg, Julio César Rendón, Marianne G. Rots, María Cristina Navas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Epigenomics
0301 basic medicine epigenome SMALL HETERODIMER PARTNER Virus Replication medicine.disease_cause Biochemistry Epigenome 0302 clinical medicine IMPLANTED NUDE-MICE Epigenoma HBV epidrugs IN-VIVO DNA methylation HEPATOCELLULAR-CARCINOMA CELLS Hepatitis B HBx 030220 oncology & carcinogenesis cccDNA OCCULT HBV INFECTION Reprogramming Metilación de ADN Hepatitis B virus Biology ARTIFICIAL TRANSCRIPTION FACTORS Virus 03 medical and health sciences CRISPR/Cas Sistemas CRISPR-Cas Epigenome editing medicine Humans HEPATOCYTE NUCLEAR FACTOR-3 Epigenetics Molecular Biology Virus de la Hepatitis B SURFACE-ANTIGEN PROMOTER virus-host interaction Cell Biology DNA Methylation Virology ZINC-FINGER NUCLEASES 030104 developmental biology Viral replication epigenome editing CRISPR-Cas Systems |
| Zdroj: | Repositorio UdeA Universidad de Antioquia instacron:Universidad de Antioquia |
| Popis: | Worldwide, chronic hepatitis B virus (HBV) infection is a major health problem and no cure exists. Importantly, hepatocyte intrusion by HBV particles results in a complex deregulation of both viral and host cellular genetic and epigenetic processes. Among the attempts to develop novel therapeutic approaches against HBV infection, several options targeting the epigenomic regulation of HBV replication are gaining attention. These include the experimental treatment with ‘epidrugs’. Moreover, as a targeted approach, the principle of ‘epigenetic editing’ recently is being exploited to control viral replication. Silencing of HBV by specific rewriting of epigenetic marks might diminish viral replication, viremia, and infectivity, even- tually controlling the disease and its complications. Additionally, epigenetic editing can be used as an experimental tool to increase our limited understanding regarding the role of epigenetic modifications in viral infections. Aiming for permanent epigenetic reprogramming of the viral genome without unspecific side effects, this breakthrough may pave the roads for an ambitious technological pursuit: to start designing a curative approach utilizing manipulative molecular therapies for viral infections in vivo. COL0024159 |
| Databáze: | OpenAIRE |
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