Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a Black population
| Autor: | Michelle Blank, Angela Manns, M. Kuwayama, Jun-mo Nam, Shunro Sonoda, Owen St. C. Morgan, Toshinobu Fujiyoshi, Shinji Yashiki, William A. Blattner, Barrie Hanchard, Rainford J. Wilks, Beverly Cranston |
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| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Population Genes MHC Class II Black People Human leukocyte antigen Biology Asymptomatic Adult T-cell leukemia/lymphoma Antigen immune system diseases hemic and lymphatic diseases Tropical spastic paraparesis medicine Odds Ratio Humans Leukemia-Lymphoma Adult T-Cell education Alleles education.field_of_study virus diseases medicine.disease biology.organism_classification Virology Oncology Human T-lymphotropic virus 1 Immunology Carrier State medicine.symptom Asymptomatic carrier |
| Zdroj: | Journal of the National Cancer Institute. 90(8) |
| ISSN: | 0027-8874 |
| Popis: | Background: Human T-cell lymphotropic virus type I (HTLV-I) is linked to adult T-cell leukemia/lymphoma (ATL) and HTLV-I-associated myelopathy (HAM; also known as tropical spastic paraparesis [TSP]), a chronic neurodegenerative disorder. Worldwide, several million HTLV-I carriers are at risk for disease, with an estimated lifetime cumulative risk of 1%-5%. However, the determinants of disease progression are relatively unknown. We studied human leukocyte antigens (HLA class II) that have been implicated in the pathogenesis of HTLV-I-related diseases. Methods: We analyzed HLA class II alleles among asymptomatic HTLV-I carriers (n = 45), patients with ATL (n = 49) or HAM/TSP (n = 54), and HTLV-I sero-negative control subjects (n = 51). All participants were of African descent and were enrolled in epidemiologic studies conducted at the University of the West Indies, Kingston, Jamaica. We used standard microlymphocyto-toxicity assays for HLA antigen serotyping and polymerase chain reaction-based methods to examine HLA class II DRB1 and DQB1 alleles. Results: Two antigens determined by serotyping, DR15 and DQ1, occurred at significantly increased frequency among HTLV-I carriers compared with sero-negative control subjects (42% versus 22% for DR15 [odds ratio {OR} = 2.7; 95% confidence interval {CI} = 1.0-7.2] and 78% versus 53% for DQ1 [OR = 3.1; 95% CI = 1.3-8.5]). Asymptomatic carriers were shown to have an HLA class II allele distribution similar to that of patients with ATL, and the frequencies of the alleles DRB1 * 1501, DRB1 * 1101, and DQB1 * 0602 were significantly greater in patients with ATL and asymptomatic carriers than in patients with HAM/TSP. In addition, haplotypes DRB1 * 1101-DQB1 * 0301 and DRB1 * 1501-DQB1 * 0602 were significantly increased among patients with ATL compared with patients with HAM/TSP. Conclusions: These data suggest that host genetic background is an important factor in determining whether HTLV-I carriers develop either ATL or HAM/TSP. |
| Databáze: | OpenAIRE |
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