Description of a short-term Taxol®-induced nociceptive neuropathy in rats
| Autor: | F. Coudoré, Nicolas Authier, Alain Eschalier, Jean-Pierre Gillet, J. Fialip |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Hot Temperature Paclitaxel Neural Conduction Pain Motor Activity Pharmacology Nerve conduction velocity Rats Sprague-Dawley medicine Animals Molecular Biology Hypoalgesia Hand Strength business.industry General Neuroscience Nociceptors medicine.disease Sciatic Nerve Rats Nociception Peripheral neuropathy Hyperalgesia Anesthesia Neuropathic pain Somatosensory Disorders Nociceptor Neuralgia Neurology (clinical) Sciatic nerve medicine.symptom business Hair Developmental Biology |
| Zdroj: | Brain Research. 887:239-249 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(00)02910-3 |
| Popis: | This work describes a new animal model of neuropathic pain produced by the single intraperitoneal administration of Taxol (32 mg/kg) to male Sprague-Dawley rats. During the course of the experiment, the clinical status of the rats remained satisfactory and motor function was not altered. A number of classical behavioural tests of nociception as well as histological and electrophysiological investigations were performed. Taxol administration produced an important and rapidly developing mechanical hyperalgesia, a thermal hypoalgesia but no mechanical or thermal allodynia. Degenerative changes were observed in the sciatic nerve, the nerve fibres in the paw subcutaneous tissue and in the lumbar spinal cord. When Taxol or vehicle (a mix of Cremophor and ethanol) were repeatedly injected once a week for 5 weeks, similar nociceptive disorders were observed in addition to a decrease in peripheral nerve conduction velocity. The selective dysfunction of high-diameter myelinated fibres observed after one single administration of Taxol (32 mg/kg) may be attributable to paclitaxel-induced neuropathy, however other mechanisms causing neurochemical dysfunction must also be involved. |
| Databáze: | OpenAIRE |
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