Effect of Growth Hormone on Body Composition and Visceral Adiposity in Middle-Aged Men with Visceral Obesity
| Autor: | Magdalena Pasarica, Stephen Redman, Steven R. Smith, Lilian deJonge, Jeffrey J. Zachwieja |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Blood Pressure Biochemistry Absorptiometry Photon Endocrinology Insulin resistance Internal medicine medicine Humans Insulin Resting energy expenditure Obesity Insulin-Like Growth Factor I Adiposity Dose-Response Relationship Drug business.industry Biochemistry (medical) Middle Aged medicine.disease Respiratory Function Tests Somatropin Adipose Tissue Growth Hormone Body Composition Lean body mass Lipid Peroxidation Insulin Resistance Metabolic syndrome Energy Metabolism Tomography X-Ray Computed business Body mass index |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 92:4265-4270 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | GH replacement in GH-deficient adults results in an improvement in metabolic status. GH might also decrease visceral adiposity in obese adults that are not GH deficient.Our objective was to determine the effects of supraphysiological GH therapy on the metabolic syndrome and visceral adiposity in men with low blood levels of IGF-I and the durability of these effects after stopping GH therapy.The study was a double-blind, placebo-controlled 6-month intervention trial followed by a blinded follow-up period of 6 months.Thirty nondiabetic middle-aged men with central adiposity (body mass index27 kg/m(2); waist circumference102 cm) participated.After 6 months of GH therapy, we observed an increase in weight and lean body mass (2.5 +/- 0.6 kg, P0.05 compared with baseline and placebo) and 8.8% reduction in visceral adiposity. GH increased resting energy expenditure by 172.5 +/- 41.6 kcal/24 h after 6 months of therapy. Fasting insulin, glucose, and the quantitative insulin sensitivity check index for insulin resistance increased during GH therapy. The effects of GH on fatness and visceral adiposity disappeared shortly after GH withdrawal, but weight remained increased over baseline and when compared with the placebo group (P0.05).These data suggest that GH therapy is associated with small but statistically significant decreases in visceral adiposity and an increase in lean mass and body weight. In viscerally obese subjects, supraphysiological GH administration is not an effective treatment; however, additional studies are needed to evaluate the effects of low-dose, physiological GH treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|