Development and characterization of niosomal gel for topical delivery of benzoyl peroxide

Autor:	Goutam Rath, Gagan Goyal, Amit K. Goyal, Tarun Garg, Basant Malik, Gaurav Chauhan
Rok vydání:	2013
Předmět:	Drug Materials science Chromatography integumentary system Contact time Drug permeation media_common.quotation_subject Pharmaceutical Science General Medicine Benzoyl peroxide Permeation medicine.disease First line treatment medicine Niosome Acne media_common medicine.drug
Zdroj:	Drug Delivery. 22:1027-1042
ISSN:	1521-0464 1071-7544
DOI:	10.3109/10717544.2013.855277
Popis:	Benzoyl peroxide (BPO) is generally considered as first line treatment against acne. Low water solubility and formation of larger clusters and limited skin permeation upon topical application necessitates the application of high amount of drug for desired action which leads to induction of skin irritation. In the present study, we developed BPO-loaded niosomal formulation to improve its permeation through skin. The niosomes were further loaded in the carbopol gel to improve contact time. The results of the skin permeation study, skin retention study revealed that niosomes can effectively improve the drug permeation through skin. Application of niosomal gel significantly reduced the bacterial load after a treatment of four days. This reduction in bacterial load was further resulted in a significant reduction in the inflammation with minimal skin irritation compared with plain drug and the plain niosomal formulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce4a5881d7a78499085a3a702cf2a64 https://doi.org/10.3109/10717544.2013.855277 Zobrazit plný text záznamu