Decrease in number of CD16(LEU 11)+CD45RA(2H4)+ cells and defective production of natural killer cytotoxic factor in childhood acute lymphoblastic leukemia
Autor: | Sachihiro Yamada, Atsushi Komiyama |
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Rok vydání: | 1991 |
Předmět: |
Adult
Cytotoxicity Immunologic Cancer Research Vincristine CD8 Antigens Prednisolone chemical and pharmacologic phenomena Receptors Fc Biology CD16 Dexamethasone Natural killer cell Interleukin 21 Antigen Antigens CD immune system diseases Histocompatibility Antigens Acute lymphocytic leukemia Antineoplastic Combined Chemotherapy Protocols medicine Asparaginase Humans Cytotoxic T cell Child Childhood Acute Lymphoblastic Leukemia Mercaptopurine Receptors IgG Proteins virus diseases hemic and immune systems HLA-DR Antigens Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Flow Cytometry medicine.disease Antigens Differentiation Molecular biology Killer Factors Yeast Killer Cells Natural Methotrexate medicine.anatomical_structure Oncology Protein Biosynthesis Immunology Leukocyte Common Antigens medicine.drug |
Zdroj: | Leukemia Research. 15:785-790 |
ISSN: | 0145-2126 |
Popis: | CD16 or CD45RA is known to be a functional molecule, which provides activation signals in natural killer (NK) cells or T cells, respectively. To dissect the decreased NK activity in childhood acute lymphoblastic leukemia (ALL), the expression of CD16 (Leu 11) or CD45RA (2H4) and the production of natural killer cytotoxic factor (NKCF) were investigated. CD16+ cells or CD45RA+ cells in peripheral blood lymphocytes were not decreased as compared with controls, however, CD16+CD45RA+ cells in ALL (4%) were lower (p less than 0.05) than controls (17%). The production of NKCF in ALL patients (9.2%) was lower (p less than 0.05) than controls (16.5). These data suggest that the decreased NK activity in ALL patients can be attributable at least in part to the functional impairment of NK cells to produce NKCF. |
Databáze: | OpenAIRE |
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