Decrease in number of CD16(LEU 11)+CD45RA(2H4)+ cells and defective production of natural killer cytotoxic factor in childhood acute lymphoblastic leukemia

Autor: Sachihiro Yamada, Atsushi Komiyama
Rok vydání: 1991
Předmět:
Adult
Cytotoxicity
Immunologic
Cancer Research
Vincristine
CD8 Antigens
Prednisolone
chemical and pharmacologic phenomena
Receptors
Fc
Biology
CD16
Dexamethasone
Natural killer cell
Interleukin 21
Antigen
Antigens
CD
immune system diseases
Histocompatibility Antigens
Acute lymphocytic leukemia
Antineoplastic Combined Chemotherapy Protocols
medicine
Asparaginase
Humans
Cytotoxic T cell
Child
Childhood Acute Lymphoblastic Leukemia
Mercaptopurine
Receptors
IgG
Proteins
virus diseases
hemic and immune systems
HLA-DR Antigens
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Flow Cytometry
medicine.disease
Antigens
Differentiation
Molecular biology
Killer Factors
Yeast
Killer Cells
Natural
Methotrexate
medicine.anatomical_structure
Oncology
Protein Biosynthesis
Immunology
Leukocyte Common Antigens
medicine.drug
Zdroj: Leukemia Research. 15:785-790
ISSN: 0145-2126
Popis: CD16 or CD45RA is known to be a functional molecule, which provides activation signals in natural killer (NK) cells or T cells, respectively. To dissect the decreased NK activity in childhood acute lymphoblastic leukemia (ALL), the expression of CD16 (Leu 11) or CD45RA (2H4) and the production of natural killer cytotoxic factor (NKCF) were investigated. CD16+ cells or CD45RA+ cells in peripheral blood lymphocytes were not decreased as compared with controls, however, CD16+CD45RA+ cells in ALL (4%) were lower (p less than 0.05) than controls (17%). The production of NKCF in ALL patients (9.2%) was lower (p less than 0.05) than controls (16.5). These data suggest that the decreased NK activity in ALL patients can be attributable at least in part to the functional impairment of NK cells to produce NKCF.
Databáze: OpenAIRE
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