Midbrain dopaminergic development in vivo and in vitro from embryonic stem cells
| Autor: | Sarah L. Maxwell, Meng Li |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Histology
Dopamine Cellular differentiation Cell Culture Techniques Review Biology Cell therapy Parkinsonian Disorders Mesencephalon In vivo Animals Humans skin and connective tissue diseases Molecular Biology Ecology Evolution Behavior and Systematics Neurons Regulation of gene expression Stem Cells Dopaminergic Genes Homeobox Gene Expression Regulation Developmental Cell Differentiation Cell Biology Anatomy Embryonic stem cell In vitro Cell culture Schizophrenia Neuroscience Developmental Biology |
| Zdroj: | Journal of Anatomy. 207:209-218 |
| ISSN: | 1469-7580 0021-8782 |
| DOI: | 10.1111/j.1469-7580.2005.00453.x |
| Popis: | The midbrain dopaminergic (mDA) neurons play a key role in the function of a variety of brain systems, including motor control and reward pathways. This has led to much interest in these neurons as targets for intervention in human disorders such as Parkinson's disease and schizophrenia. A major area of interest is to direct embryonic stem (ES) cells to differentiate into mDA neurons in vitro, which can then be used for cell therapy or drug screening. At present, our understanding of mDA development in vivo is limited. However, recent studies have identified a number of regulatory factors that influence the development of mDA neurons in vivo. Such studies will not only increase our understanding of mDA development in vivo, they may also promote new paradigms for regulating mDA production from ES cells in vitro. Here we review the current knowledge on mDA development in vivo and mDA differentiation. |
| Databáze: | OpenAIRE |
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