Comparison of the Emetogenic Potential Between Cisplatin and Carboplatin in Combination with Alkylating Agents
| Autor: | Ulrich Karck, Hans Gerd Meerpohl, Andreas du Bois, Christoph Thomssen, Helmut Madjar, Heiner Prompeler, Werner Vach |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Oncology
medicine.medical_specialty Time Factors endocrine system diseases Vomiting medicine.drug_class medicine.medical_treatment Uterine Cervical Neoplasms Carboplatin Ondansetron chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Antiemetic Radiology Nuclear Medicine and imaging Ifosfamide Cyclophosphamide Ovarian Neoplasms Cisplatin Chemotherapy business.industry Hematology General Medicine Middle Aged Gynecological cancer female genital diseases and pregnancy complications Clinical trial chemistry Female business medicine.drug |
| Zdroj: | Acta Oncologica. 33:531-535 |
| ISSN: | 1651-226X 0284-186X |
| Popis: | Platinum-based polychemotherapy is widely used in the treatment of gynecological cancer. Emesis is one of the most disturbing side-effects of platinum therapy. We performed a study to evaluate and compare the emetogenic potential and the different emesis pattern after cisplatin and carboplatin under antiemetic treatment with ondansetron. One hundred and twenty-two patients with either cisplatin-containing (n = 70) or carboplatin-containing (n = 52) first-line chemotherapy were included. Treatment with cisplatin led more frequently to emesis and patients suffered from more severe emesis than carboplatin treated patients. Delayed emesis was observed after both platinum analogues but occurred more frequently and lasted longer after cisplatin. |
| Databáze: | OpenAIRE |
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