Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
| Autor: | Fernando Teodoro, M. Manuela L. Ribeiro Carrott, Rui Pedrosa, Luís Filipe, Luís C. Branco, Celso Alves, Sandra Gago, Andreia Forte, Blanca de Juan Mora, Miguel M. Santos |
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| Přispěvatelé: | DQ - Departamento de Química, LAQV@REQUIMTE |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Mesoporous silica nanoparticles
Cytotoxicity Pharmaceutical Science Nanoparticle lcsh:RS1-441 02 engineering and technology Antimicrobial activity 010402 general chemistry 01 natural sciences Article Nanomaterials lcsh:Pharmacy and materia medica ionic liquids chemistry.chemical_compound Adsorption ciprofloxacin Ciprofloxacin mesoporous silica nanoparticles antimicrobial activity Mesoporous silica 021001 nanoscience & nanotechnology Antimicrobial 0104 chemical sciences Ionic liquids chemistry Ionic liquid Surface modification cytotoxicity 0210 nano-technology Mesoporous material Nuclear chemistry |
| Zdroj: | Pharmaceutics Pharmaceutics, Vol 13, Iss 218, p 218 (2021) Volume 13 Issue 2 Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | Funding Information: Funding: This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively). Funding Information: Acknowledgments: The authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanomaterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin. publishersversion published |
| Databáze: | OpenAIRE |
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