Inflammatory mediators in autotransfusion drain blood after knee arthroplasty, with and without leucocyte reduction
| Autor: | B. Brorsson, Anders Bengtsson, T. Dalén, K. G. Engström |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Inflammation Cell Separation Gastroenterology Proinflammatory cytokine Blood Transfusion Autologous Leukocyte Count Internal medicine Leukocytes medicine Humans Arthroplasty Replacement Knee Complement Activation Aged Postoperative Care Tumor Necrosis Factor-alpha business.industry Interleukin-8 Elastase Interleukin Hematology General Medicine Venous blood Complement system Immunology Cytokines Drainage Female Inflammation Mediators medicine.symptom business Filtration Autotransfusion |
| Zdroj: | Vox Sanguinis. 85:31-39 |
| ISSN: | 1423-0410 0042-9007 |
| Popis: | Background and Objectives The aim of this study was to evaluate whether leucocyte-reducing filters influenced complement activation and the formation of pro-inflammatory cytokines in autotransfusion drain blood after knee arthroplasty. Materials and Methods Twenty-three patients undergoing knee arthroplasty were divided into two groups. All patients were given salvage blood postoperatively. In Group A, a leucocyte filter was connected between the wound and the drain blood container. In Group B the drain blood was not leucocyte filtered. Complement split products and cytokines were analysed in circulating blood and in drain blood, together with blood-cellular differential counts. Results Drain blood showed activation vs. venous blood, with elevated concentrations of C3a, SC5b-9, interleukin (IL)-6, IL-8, polymophonuclear (PMN) elastase and tumour necrosis factor-α (TNF-α) (P |
| Databáze: | OpenAIRE |
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