Radiotherapy of nasopharyngeal cancer using Rapidarc: dosimetric study of military teaching hospital Mohamed V, Morocco

Autor: Mohamed Elmarjany, I. Lalya, Keltoum Dahmani, Hassan Sifat, Maghous Abdelhak, Noha Zaghba, Khalid Andaloussi, Khalid Hadadi, Laila Baddouh, El Amin Marnouche, Hamid Mansouri
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
Mucositis
medicine.medical_specialty
Intensity-modulated radiotherapy
medicine.medical_treatment
Nasopharyngeal cancer
Planning target volume
Dermatitis
Hospitals
Military
Xerostomia
General Biochemistry
Genetics and Molecular Biology
030218 nuclear medicine & medical imaging
Teaching hospital
Late toxicity
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Hearing Loss
Hospitals
Teaching
Radiometry
Retrospective Studies
Medicine(all)
Volumetric-modulated arc therapy
business.industry
Biochemistry
Genetics and Molecular Biology(all)
Radiotherapy Planning
Computer-Assisted
Nasopharyngeal Neoplasms
Radiotherapy Dosage
General Medicine
Middle Aged
Surgery
Conformity index
Radiation therapy
Morocco
Treatment Outcome
030220 oncology & carcinogenesis
Female
Radiotherapy
Intensity-Modulated
Accelerated Radiation Therapy
Intermediate risk
Nuclear medicine
business
Research Article
Zdroj: BMC Research Notes
ISSN: 1756-0500
Popis: Background The aim of the present study is to assess efficacy and efficiency of Volumetric-modulated arc therapy (VMAT) technique in treatment of nasopharyngeal cancer in our institution and to report toxicity related to this technique. Methods Between June 2013 and January 2015, thirty-two patients with non metastatic nasopharyngeal cancer were curatively treated using VMAT Rapidarc. Dose prescription was performed using two different schedules, it consisted of either simultaneous integrated boost or simultaneous modulated accelerated radiation therapy delivering 70 Gy in 35 fractions and 69.96 in 33 fractions respectively. The choice was leaved at the discretion of the treating physician. The optimization process was performed by Eclipse software version 10.0 (Varian Medical Systems), using PRO algorithm (Progressive resolutive optimisation) version 3. Data was collected from dose-volume histograms for both planning target volumes (PTV) and organs at risk (OAR). We calculated the homogeneity index and the conformity index as well as the number of monitor units MU and the treatment delivery time. We also reported acute and late toxicity related to radiation therapy. Results For the PTV high risk (HR), intermediate risk (PTV IR) and low risk (LR) the D95% was 97.21 ± 1.5, 97.5 ± 3.3 and 97.10 ± 6.86 respectively. Whereas, The D5% was 104.6 ± 2.16, 103.8 ± 2.1 and 100.89 ± 7.26. The CI for PTV HR was 0.98 ± 0.02 and the HI was 0.08 ± 0.02. The mean treatment delivery time was 2.3 ± 0.2, and the mean MU number was 527.6 ± 131.4. Grade 4 toxicity was not reported in any case. Grade 3 xerostomia was observed in only 3(9.4%) patients and no patients developed grade 3 hearing loss. Conclusion Our results confirmed the abilities of VMAT to provide excellent coverage of target volumes while sparing OAR especially the nervous structures and salivary glands.
Databáze: OpenAIRE
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