| Autor: |
Valentina Botondi, Alice Pirra, Mariachiara Strozzi, Marika Perrotta, Danilo A.W. Gavilanes, Laura Di Ricco, Cynzia Spagnuolo, Antonio Maconi, Andrea Rocchetti, Laura Mazzucco, Valeria Balbo, Federico Schena, Giuseppina Stellitano, Arianna Oddi, Andrea Dotta, Iliana Bersani, Andrea Sannia, Chiara Peila, Enrico Bertino, Ines Bianco, Alessandra Gambi, Rocco Mangifesta, Diego Gazzolo |
| Přispěvatelé: |
RS: GROW - R4 - Reproductive and Perinatal Medicine, RS: MHeNs - R3 - Neuroscience, Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9) |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical Chemistry and Laboratory Medicine, 60(5), 793-799. Walter de Gruyter GmbH |
| ISSN: |
1434-6621 |
| DOI: |
10.1515/cclm-2022-0027 |
| Popis: |
Objectives Standard of care sepsis biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) can be affected by several perinatal factors, among which perinatal asphyxia (PA) has a significant role. In this light, new early sepsis biomarkers such as presepsin (P-SEP) are needed to enact therapeutic strategies at a stage when clinical and laboratory patterns are still silent or unavailable. We aimed at investigating the potential effects of PA on longitudinal P-SEP urine levels. Methods We conducted an observational case-control study in 76 term infants, 38 with PA and 38 controls. Standard clinical, laboratory, radiological monitoring procedures and P-SEP urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Results Higher (p0.05, for all) at T0 were observed between groups. P-SEP urine levels were higher (p0.05) at 48 and 96 h were observed. No significant correlations were found (p>0.05) between P-SEP and urea (R=0.11) and creatinine (R=0.02) blood levels, respectively. Conclusions The present results, showed that PA effects on P-SEP were limited up to the first 24 h following birth in absence of any kidney function bias. Data open the way to further investigations aimed at validating P-SEP assessment in non-invasive biological fluids as a reliable tool for early EOS and LOS detection in high-risk infants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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