Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema
| Autor: | Yukio Hirata, Takasuke Imai, Kuninori Yokoyama, Kenichiro Habuka, Yutaka Narumi, Koshi Makita, Chieko Mitaka |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Hemodynamics Pulmonary Edema Kidney Critical Care and Intensive Care Medicine Dogs Atrial natriuretic peptide Furosemide Edema Internal medicine medicine Animals Diuretics Lung Pulmonary Gas Exchange business.industry Respiratory disease Pulmonary edema medicine.disease Surgery medicine.anatomical_structure Extravascular Lung Water Cardiology medicine.symptom business Atrial Natriuretic Factor Oleic Acid medicine.drug |
| Zdroj: | Critical Care Medicine. 30:1570-1575 |
| ISSN: | 0090-3493 |
| Popis: | The purpose of this study was to examine and compare the effects of atrial natriuretic peptide and furosemide on pulmonary gas exchange, hemodynamics, extravascular lung water, and renal function in a dog model of oleic acid-induced pulmonary edema.Prospective, comparable, experimental study.Laboratory at a university hospital.Eighteen male beagle dogs were studied under mechanical ventilation with pentobarbital anesthesia.Oleic acid (0.08 mL/kg) was injected and allowed for 1 hr to achieve pulmonary edema with hypoxemia at Fio2 of 0.3. After lung injury, dogs were divided into three groups; control group (n = 6) receiving saline (2.5 mL/hr for 5 hrs), atrial natriuretic peptide group (n = 6) receiving atrial natriuretic peptide (1 microg x kg(-1) x min(-1) for 5 hrs), and furosemide group (n = 6) receiving furosemide (1 mg x kg(-1) x hr(-1) for 5 hrs).Hemodynamics, arterial blood gases, extravascular lung water, and renal function were measured hourly for 7 hrs after injury. Oleic acid increased extravascular lung water and induced hypoxemia. In the atrial natriuretic peptide group, extravascular lung water was significantly (p.05) lower and Pao2 was significantly (p.05) higher than in the control and furosemide groups, respectively. Pulmonary hypertension induced by oleic acid was attenuated by atrial natriuretic peptide infusion but not by saline or furosemide. Increased natriuresis/diuresis did not significantly differ between the atrial natriuretic peptide and the furosemide group, whereas creatinine clearance in the atrial natriuretic peptide group was significantly higher than that in the furosemide group.These findings suggest that atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water and pulmonary arterial pressure, possibly independently from natriuresis/diuresis in oleic acid-induced pulmonary edema. |
| Databáze: | OpenAIRE |
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