Role of 11C-choline PET/CT in the re-staging of prostate cancer patients with biochemical relapse and negative results at bone scintigraphy
| Autor: | Gian Carlo Montini, Stefano Fanti, Pier Luigi Guidalotti, Gilberto Gavaruzzi, Maria Cristina Marzola, Chiara Fuccio, Riccardo Schiavina, Domenico Rubello, Cristina Nanni, Paolo Castellucci |
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| Přispěvatelé: | FUCCIO C., CASTELLUCCI P., SCHIAVINA R., GUIDALOTTI PL., GAVARUZZI G., MONTINI G.C., NANNI C., MARZOLA MC., RUBELLO D., FANTI S. |
| Rok vydání: | 2011 |
| Předmět: |
Biochemical recurrence
Male medicine.medical_specialty medicine.medical_treatment Multimodal Imaging Sensitivity and Specificity Bone and Bones Choline Prostate cancer Biopsy medicine Biomarkers Tumor Humans Radiology Nuclear Medicine and imaging Carbon Radioisotopes Aged Neoplasm Staging Aged 80 and over Lung medicine.diagnostic_test business.industry Prostatectomy Prostatic Neoplasms Reproducibility of Results Retrospective cohort study General Medicine Middle Aged Prostate-Specific Antigen prostate cancer medicine.disease 11C-choline PET/CT medicine.anatomical_structure Bone scintigraphy Positron emission tomography Positron-Emission Tomography biochemical relapse Radiology Neoplasm Recurrence Local Nuclear medicine business Tomography X-Ray Computed |
| Zdroj: | European journal of radiology. 81(8) |
| ISSN: | 1872-7727 |
| Popis: | Aim to evaluate the utility of 11 C-choline PET/CT in prostate cancer (PC) patients who have demonstrated a biochemical recurrence and a negative bone scintigraphy (BS). Materials and methods 123 consecutive PC patients (mean age 67.6 years; range 54–83) with a biochemical relapse (mean PSA value 3.3ng/mL; range 0.2–25.5) after radical prostatectomy (RP) were included in our retrospective study. Patients underwent a BS that resulted negative and a 11 C-choline PET/CT within 4 months from BS (range: 1 day to 4 months; mean: 2.5 months). Validation of results was established by: (1) a positive biopsy, (2) a positive subsequent BS, CT or MR and (3) a normalization of 11 C-choline uptake after systemic therapy or a progression of the disease. Results 11 C-choline PET/CT was positive in 42/123 patients (34.1%). 11 C-choline PET/CT detected lesions in: bone (10 patients), lymph-nodes (20 patients), bone and lymph nodes (7 patients), bone and lung (1 patient), lymph-nodes and lung (1 patient), local relapse (3 patients). Overall, 11 C-choline PET/CT showed a total of 30 unknown bone lesions in 18/123 (14.6%) patients. Conclusion 11 C-choline PET/CT showed a better sensitivity than BS in patients with biochemical relapse after RP: 11 C-choline PET/CT detected unknown bone lesions in 18/123 (14.6%) patients. |
| Databáze: | OpenAIRE |
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