Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity
| Autor: | Mitsuru Ueda, Takashi Suzuki, Yusuke Sugata, Takumi Furuta, Yasuo Hirooka, Ayako Abe, Kouki Murakami, Toshiyuki Kan, Kiyoshi Tanaka |
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| Rok vydání: | 2007 |
| Předmět: |
Influenzavirus A
Ketone Stereochemistry Clinical Biochemistry Orthomyxoviridae Pharmaceutical Science Epigallocatechin gallate Antiviral Agents complex mixtures Biochemistry Chemical synthesis Catechin Virus chemistry.chemical_compound Dogs Drug Discovery Animals heterocyclic compounds Molecular Biology Cells Cultured chemistry.chemical_classification Dideoxy-epigallocatechin gallate biology Organic Chemistry food and beverages Biological activity General Medicine Gallate biology.organism_classification chemistry Molecular Medicine Epimer sense organs |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:3095-3098 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2007.03.041 |
| Popis: | Dideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG (1), was efficiently prepared by directly introducing a ketone group at C3 and successive reduction to the sec-alcohol with 2,3-cis stereochemistry. Compound 2 showed potent anti-influenza virus activity, indicating that the hydroxyl substituents on the A-ring are not crucial for anti-influenza virus activity. |
| Databáze: | OpenAIRE |
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