MAJOR UPPER GASTROINTESTINAL HAEMORRHAGE ASSOCIATED WITH HEPATIC ARTERIAL CHEMOPERFUSION
| Autor: | William Ross, Philip R. Clingan, David L. Morris |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer Gastroduodenal artery Hepatic Artery Upper gastrointestinal haemorrhage medicine.artery medicine Humans Infusions Intra-Arterial Upper gastrointestinal Aged Aged 80 and over business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Thrombosis Extravasation Surgery Peptic Ulcer Hemorrhage medicine.anatomical_structure Duodenal Ulcer Duodenum Female Fluorouracil Radiology Colorectal Neoplasms Gastrointestinal Hemorrhage business Artery |
| Zdroj: | ANZ Journal of Surgery. 66:816-819 |
| ISSN: | 1445-2197 1445-1433 |
| DOI: | 10.1111/j.1445-2197.1996.tb00756.x |
| Popis: | Background: The present study reviews the nature of upper gastrointestinal complications of hepatic arterial chemoperfusion at a tertiary referral centre for the treatment of hepatic malignancy. Methods: The patients involved in the present study all had major upper gastrointestinal (GI) haemorrhage and were undergoing hepatic arterial chemoperfusion. Results: Eight patients had major upper GI haemorrhage. Three of these patients were not referred for surgical management, and all three patients died. The five patients who were admitted or transferred to our unit and who underwent surgery all survived. Conclusions: These complications are probably caused by extravasation of 5-fluorouracil (5-FU) following thrombosis of the gastroduodenal artery. The resulting cavity may perforate into the hepatic artery, portal vein, duodenum or biliary tree. Surgeons and oncologists should be aware of these complications. If upper abdominal pain occurs, chemoperfusion should cease immediately and an urgent investigation, which may include catheter angiography, gastroscopy and computed tomography (CT) scanning. should be carried out to exclude an hepatic artery pseudo-aneurysm. |
| Databáze: | OpenAIRE |
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