Electrospinning fabrication of high-trackable catheter tip with gradually graded or gradient flexibility

Autor:	Daigo Kawahara, Takehisa Matsuda
Rok vydání:	2008
Předmět:	Fabrication Materials science Polyurethanes Biomedical Technology Biomedical Engineering Elastomer Electrospinning Catheterization Biomaterials Mandrel Elastomers Deflection (engineering) Composite material Pliability Wall thickness Biomedical engineering
Zdroj:	Journal of Biomedical Materials Research Part B: Applied Biomaterials. :35-41
ISSN:	1552-4981 1552-4973
DOI:	10.1002/jbm.b.31061
Popis:	Increasing demand for a flexible catheter tip exists in the rapidly growing fields of vascular and interventional radiology. This article describes a fabrication technology producing a catheter tip with gradually graded or gradient flexibility. Based on deflection mechanics of a tubular construct, three models were incorporated into structural designs. The models included graded wall thickness, tapered shape, or graded Young's moduli. Electrospinning using elastomeric polymer [poly(L-lactide-co-e-caprolactone), polyurethane] solutions on a transversely and rotationally moving mandrel enabled preparation of three prototype tubular tips by either regio-specific control of wall thickness, tapered mandrel, or regiospecific deposition of polyurethanes with different Young's moduli. All prototype tips exhibited high flexibility at tip ends, as verified using a bifurcated vessel model. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd9dd2926223f4796fb65825e102783 https://doi.org/10.1002/jbm.b.31061 Zobrazit plný text záznamu Plný text