Localization of parathyroid tumours in the minimally invasive era: which technique should be chosen? Population-based analysis of 253 patients undergoing parathyroidectomy and factors affecting parathyroid gland detection
| Autor: | Mario Ermani, Gennaro Favia, Franco Lumachi, Smm Basso, N Borsato, Pietro Zucchetta |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Cancer Research Endocrinology Diabetes and Metabolism medicine.medical_treatment specificity Parathyroid hormone Primary hyperparathyroidism Hyperparathyroidism Parathyroid disease Parathyroidectomy PTH Hypercalcemia calcium Parathyroid scintigraphy scintigraphy MIBI parathyroid glands CT neck ultrasonography 99mTc MRI sensitivity specificity Scintigraphy Endocrinology scintigraphy Medicine Ultrasonography Aged 80 and over medicine.diagnostic_test Hyperparathyroidism Subtraction Middle Aged Magnetic Resonance Imaging Parathyroid Neoplasms medicine.anatomical_structure Oncology Parathyroid Hormone Parathyroid disease Female Radiology PTH CT MRI Adult Technetium Tc 99m Sestamibi Parathyroidectomy medicine.medical_specialty Adolescent neck ultrasonography Population based Humans MIBI Radionuclide Imaging Aged Sodium Pertechnetate Tc 99m 99mTc calcium business.industry Parathyroid scintigraphy Magnetic resonance imaging sensitivity medicine.disease Thallium Radioisotopes Hypercalcemia parathyroid glands Parathyroid gland Tomography X-Ray Computed business |
| Zdroj: | Endocrine-related cancer. :63-69 |
| ISSN: | 1351-0088 |
| DOI: | 10.1677/erc.0.0080063 |
| Popis: | A series of 253 consecutive patients with proved primary hyperparathyroidism due to parathyroid tumours was reviewed. There were 68 (26.9%) men and 185 (73.1%) women, with a median age of 57 years (range 13-82 years). All patients, prior to successful parathyroidectomy, underwent one or more preoperative localization procedures such as: neck ultrasonography (US) in 191 (75.5%), (201)Tl/(99m)Tc-pertechnetate subtraction scintigraphy (TPS) in 144 (56.9%), CT scan in 92 (36.4%), (99m)Tc-sestamibi/(99m)Tc-pertechnetate subtraction scintigraphy (MPS) in 90 (35.6%), selective venous sampling (SVS) with parathyroid hormone (PTH) assay in 30 (11.9%), and magnetic resonance imaging (MRI) in 6 (2.4%) patients. The results were compared with operative and histological findings that showed 235 (92.9%) solitary parathyroid adenomas, 13 (5.1%) carcinomas and 5 (2.0%) double adenomas. Sensitivity and positive predictive value were 82.9% and 93.8% for US, 83.6% and 91.8% for TPS, 81.3% and 98.7% for CT scan, 85.1% and 96.1% for MPS, 65.4% and 80.9% for SVS, and 80.0% and 80.0% for MRI respectively. No different results (P=NS) were found using US, TPS, MPS or CT scan, whereas SVS and MRI sensitivity was lower (P |
| Databáze: | OpenAIRE |
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