Novel Terpenoids from Calocedrus macrolepis var. formosana
| Autor: | Ching-Chuan Kuo, Ryh-Nan Pan, Tzong-Huei Lee, Jang Yang Chang, Mei-Hwei Tseng, Yueh-Hsiung Kuo, Chin-Lin Hsieh |
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| Rok vydání: | 2011 |
| Předmět: |
Bioengineering
Biochemistry Inhibitory Concentration 50 Cell Line Tumor Botany Humans Calocedrus macrolepis var. formosana Nuclear Magnetic Resonance Biomolecular Molecular Biology Molecular Structure biology Terpenes Chemistry Cupressaceae General Chemistry General Medicine Calocedrus macrolepis biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid Epidermoid carcinoma visual_art Carcinoma Squamous Cell Plant Bark visual_art.visual_art_medium Molecular Medicine Mouth Neoplasms Bark Drug Screening Assays Antitumor |
| Zdroj: | Chemistry & Biodiversity. 8:1901-1907 |
| ISSN: | 1612-1872 |
| DOI: | 10.1002/cbdv.201000237 |
| Popis: | Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C(20)-C(10) skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC(50) value of 9.0±0.1 μM. |
| Databáze: | OpenAIRE |
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