Prognostic importance of Claudin-1 and Claudin-4 expression in colon carcinomas
| Autor: | Sevdegül Mungan, Safak Ersoz, Havvanur Turgutalp, Yavuz Ozoran, Umit Cobanoglu |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty endocrine system diseases Colorectal cancer urologic and male genital diseases digestive system Pathology and Forensic Medicine Adenomatous Polyps Young Adult Claudin-1 Biomarkers Tumor medicine Humans Mucinous carcinoma Claudin-4 Claudin Lymph node Aged Aged 80 and over Tight junction business.industry Membrane Proteins Cancer Cell Biology Middle Aged Prognosis medicine.disease Adenocarcinoma Mucinous Immunohistochemistry female genital diseases and pregnancy complications digestive system diseases medicine.anatomical_structure Lymphatic Metastasis Colonic Neoplasms Adenocarcinoma Female Lymph Nodes business |
| Zdroj: | Pathology - Research and Practice. 207:285-289 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/j.prp.2011.01.011 |
| Popis: | In this study, we analyzed Claudin-1 and Claudin-4 expressions in colon carcinomas. We investigated the relationship between the expression of these tight junction proteins and clinicopathologic parameters. Claudin-1 and 4 expressions were determined by immunohistochemical methods, and the rate of cells expressing these tight junction proteins were calculated with stereologic methods. Fifty-nine colon cancer cases were enrolled in the study group. Claudin-1 and 4 expressions were found to be significantly lower in cases with lymph node metastasis. Mean staining rates of Claudin-1 and 4 in lymph node (+) cases were 36.1±20.1 and 58±28.9, while in lymph node (-) cases, these were 63.8±25.9 and 72.3±25.6, respectively (p=0.0005 for Claudin-1, p=0.049 for Claudin-4). The mean staining rate for Claudin-1 in adenomatous polyps was significantly higher than incarcinomas (77.13±23.4 and 50.6±26.93, respectively) (p=0.003), while it was quite similar for Claudin-4 (65.4±26.9 and 65.3±27.9, respectively). In this study, we demonstrated Claudin-1 and 4 expressions in colon cancer cases. Claudin-1 expression seems to be more prominent in adenomatous polyps as compared with cancer cases. Expression of Claudin-1 decreases significantly in the presence of lymph node metastasis and diminishes in mucinous carcinoma cases, indicating a negative correlation between Claudin-1 expression and neoplastic progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect