Mild Hyperhomocysteinemia is an Independent Risk Factor of Arterial Vascular Disease
| Autor: | Godfried H.J. Boers |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Hyperhomocysteinemia Homocysteine Arteriosclerosis Coronary Disease Comorbidity Placebo chemistry.chemical_compound Folic Acid Meta-Analysis as Topic Risk Factors Internal medicine medicine Humans Multicenter Studies as Topic Genetic Predisposition to Disease Vitamin B12 Risk factor Clinical Trials as Topic diagnose en behandeling van milde vormen [Hyperhomocysteinemie] business.industry Vascular disease Smoking Case-control study Pyridoxine Hematology medicine.disease diagnosis and treatment of mild abnormalities. [Hyperhomocysteinemia] Oxidative Stress Vitamin B 12 B vitamins Endocrinology chemistry Case-Control Studies Hypertension Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Seminars in Thrombosis and Hemostasis, 26, 291-5 Seminars in Thrombosis and Hemostasis, 26, 3, pp. 291-5 |
| ISSN: | 1098-9064 0094-6176 |
| DOI: | 10.1055/s-2000-8096 |
| Popis: | Evidence of a positive association between mild hyperhomocysteinemia and arterial vascular disease has been accumulating in the last decade. Mild hyperhomocysteinemia acts as an independent vascular risk factor with equal strength as hypercholesterolemia and smoking. If jointly present with hypertension and smoking, its effect seems synergistic. This could make the outcome of homocysteine-lowering intervention beneficial, particularly in cases with concomitance of conventional vascular risk factors. So far, however, data on the clinical outcome of homocysteine-lowering treatment with a simple, safe, and cheap vitamin regimen are lacking. Trials investigating a beneficial clinical effect of homocysteine-lowering treatment using folic acid in a dose ranging from 0.2 to 5 mg daily, alone or in combination with vitamin B12 with or without vitamin B6 versus placebo, are ongoing. Furthermore, exploration of the unifying mechanism by which increased homocysteine levels may lead to both arterial and venous occlusions is warranted. These lines of investigations have to provide the ultimate proof of causality of hyperhomocysteinemia in vascular disease in the near future. |
| Databáze: | OpenAIRE |
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