Alpha-2-macroglobulin and hyaluronic acid as fibromarkers in patients with chronic hepatitis C
| Autor: | L Turecky, B Pitekova, V. Kupčová, V Mojto, E Uhlikova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Liver Cirrhosis Male 0301 basic medicine Economics and Econometrics medicine.medical_specialty Liver fibrosis Population Enzyme-Linked Immunosorbent Assay Gastroenterology alpha-2-Macroglobulin 03 medical and health sciences chemistry.chemical_compound Chronic hepatitis Internal medicine Hyaluronic acid Materials Chemistry Media Technology Humans Medicine In patient Hyaluronic Acid skin and connective tissue diseases education education.field_of_study biology business.industry Case-control study Forestry Hepatitis C Chronic Prognosis Pregnancy-Associated alpha 2-Macroglobulins 030104 developmental biology chemistry Case-Control Studies Etiology biology.protein Female alpha-Fetoproteins business Biomarkers |
| Zdroj: | Bratislava Medical Journal. 118:658-661 |
| ISSN: | 1336-0345 |
| Popis: | BACKGROUND Liver fibrosis is the final common pathway of chronic liver diseases of various etiology. From the practical standpoint, it would be ideal to have a noninvasive fibromarker. The aim of our study was to investigate the levels of alpha-2-macroglobulin, potential fibromarker, in correlation to histological staging and another potential fibromarker, hyaluronic acid, in patients with chronic hepatitis C. METHODS Population groups in this study consisted of 51 healthy volunteers and 54 patients with chronic hepatitis C. Liver biopsies were obtained under ultrasound guidance. Alpha-2-macroglobulin was determined by electroimmunodiffusion and hyaluronic acid with enzyme-linked binding protein assay. RESULTS Both potential fibromarkers, alpha-2-macroglobulin and hyaluronic acid, were increased in patients with chronic hepatitis C. The alpha-2-macroglobulin levels were not significantly increased in the groups F0-F1. In the groups F2-F4, alpha-2-macroglobulin levels were significantly higher than in the control group. The changes of hyaluronic acid were similar to changes of alpha-2-macroglobulin. Regression analysis showed a significant correlation between hyaluronic acid and alpha-2-macroglobulin levels. CONCLUSIONS According to the results of our study, it can be concluded that alpha-2-macroglobulin and hyaluronic acid might be useful markers of liver fibrosis (Tab. 2, Ref. 15). |
| Databáze: | OpenAIRE |
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