A behavioral economic analysis of the value-enhancing effects of nicotine and varenicline and the role of nicotinic acetylcholine receptors in male and female rats
| Autor: | Scott T. Barrett, Rick A. Bevins, Trevor N. Geary, Amy N. Steiner |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Nicotine Receptors Nicotinic Pharmacology Stimulus (physiology) Article Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Nicotinic Agonists Reinforcement Varenicline Acetylcholine receptor Bupropion Sex Characteristics Dose-Response Relationship Drug Economics Behavioral Dihydro-beta-Erythroidine Rats 030227 psychiatry Psychiatry and Mental health Nicotinic agonist chemistry Conditioning Operant Female Cues Reinforcement Psychology Locomotion Photic Stimulation 030217 neurology & neurosurgery medicine.drug Sex characteristics |
| Zdroj: | Behavioural Pharmacology. 29:493-502 |
| ISSN: | 0955-8810 |
| DOI: | 10.1097/fbp.0000000000000404 |
| Popis: | Reinforcement value enhancement by nicotine of non-nicotine rewards is believed to partially motivate smoking behavior. Recently, we demonstrated that the value-enhancing effects of nicotine are well characterized by reinforcer demand models, and that the value-enhancing effects of the smoking cessation aid bupropion (Zyban®) are distinct from those of nicotine and differ between the sexes (Barrett et al., 2017). The present study evaluated potential sex differences in the enhancement effects of nicotine and varenicline (Chantix®) using a reinforcer demand methodology. The role of α4β2* and α7 nicotinic acetylcholine receptors (nAChRs) in the enhancing effects of nicotine and varenicline are also evaluated. Male and female rats (n=12/sex) were trained to lever-press maintained by sensory reinforcement via visual stimulus (VS) presentations. Changes in VS value following nicotine and varenicline administration were assessed using an established reinforcer demand approach. Subsequently, the effects of antagonism of α4β2* and α7 nAChRs on varenicline and nicotine induced enhancement active lever-pressing was assessed using a progressive ratio schedule. Nicotine and varenicline enhanced VS demand equivalently between the sexes as evaluated by reinforcer demand. However, α4β2* receptor antagonism attenuated value enhancement by nicotine and varenicline in females, but only of nicotine in males. |
| Databáze: | OpenAIRE |
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