Effects of Methyllycaconitine and Related Analogues on Bovine Adrenal α3β4* Nicotinic Acetylcholine Receptors
| Autor: | Sara M Thomasy, K. A. Ismail, David J. Lapinsky, Dennis B. McKay, Stephen C. Bergmeier, Kristjan M. Arason, R. Benjamin Free, Darrell L. Bryant |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Aconitine Nicotinic Antagonists Receptors Nicotinic General Biochemistry Genetics and Molecular Biology Inhibitory Concentration 50 chemistry.chemical_compound Ganglion type nicotinic receptor History and Philosophy of Science Internal medicine Adrenal Glands medicine Animals Secretion Bovine adrenal Receptor Cells Cultured Acetylcholine receptor Methyllycaconitine General Neuroscience Endocrinology Nicotinic agonist Models Chemical chemistry Cattle Alpha-4 beta-2 nicotinic receptor |
| Zdroj: | Annals of the New York Academy of Sciences. 971:139-141 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2002.tb04448.x |
| Popis: | Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds. |
| Databáze: | OpenAIRE |
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