HIV Prophylaxis in High Risk Newborns: An Examination of Sociodemographic Factors in an Inner City Context

Autor: Jay MacGillivray, Evan Taerk, Anne E Wormsbecker, Zenita Alidina, Marcelo L. Urquia, Douglas M Campbell, Mark H. Yudin
Rok vydání: 2016
Předmět:
Zdroj: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2016 (2016)
ISSN: 1918-1493
1712-9532
DOI: 10.1155/2016/2782786
Popis: Background.Perinatal HIV transmission is less than 1% with antiretroviral (ARV) prophylaxis. Transmission risk appears higher in “high risk” dyads, yet this is not well defined, possibly exposing more infants to combination ARV compared with standard care.Objective.To describe characteristics of mother-infant dyads where infants received ARVs and how these characteristics relate to specific ARV regimens.Methods.Retrospective chart review of ARV-receiving newborns at St. Michael’s Hospital from 2007 to 2012 (and their mothers). Numerical and categorical variables were analyzed usingt-tests/ANOVAF-tests and Fisher’s exact tests, respectively.Results.Maternal HIV status at delivery was as follows: 69% positive and 24% unknown. Maternal factors significantly associated with newborn-triple therapy are Canadian origin, substance abuse, unstable housing, lost custody of previous children, and sex work. Neonatal factors are child protective services involvement, NICU, and lengthier admission. Maternal factors associated with monotherapy are African origin, HIV-positive, employment, and education. Further analysis based on maternal presentation at delivery demonstrated unequal distribution of many aforementioned factors.Discussion.This cohort revealed associations between particular factors and newborn-monotherapy or triple therapy that exist, suggesting that sociodemographic factors may influence the choice of ARV regimen. Canadian perinatal HIV transmission guidelines should qualify how to risk stratify newborns and consider use of rapid HIV antibody testing.
Databáze: OpenAIRE
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