| Autor: |
Camilla Göktürk, Elisee Wiita, Olga Loseva, Oliver Mortusewicz, Armando Cázares-Körner, Per Artursson, Aleksandr Manoilov, Mikael Altun, Petar Iliev, Ann-Sofie Jemth, Dag Ivanic, Annika Jenmalm Jensen, Roman A. Zubarev, Evert Homan, Azita Rasti, Thomas Helleday, Lang Pan, Istvan Boldogh, Catharina Von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Wenjing Hao, Pawel Baranczewski, Martin Scobie, Bishoy M. F. Hanna, Therese Pham, Ulrika Warpman Berglund, Stella Karsten, Cynthia B.J. Paulin, Geoffrey Masuyer, Antonio Sarno, Pål Stenmark, Torkild Visnes, Juan Astorga-Wells, Christina Kalderén, Olov A. Wallner, Kumar Sanjiv, Xueqing Ba, Maurice Grube, Hans E. Krokan |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Science |
| Popis: |
DNA binding as an anti-inflammatory Mice that lack the gene encoding 8-oxoguanine DNA glycosylase 1 (OGG1) show resistance to inflammation. This enzyme binds to sites of oxidative DNA damage and initiates DNA base excision repair. Visnes et al. developed a small-molecule drug that acts as a potent and selective active-site inhibitor that stops OGG1 from recognizing its DNA substrate (see the Perspective by Samson). The drug inhibited DNA repair and modified OGG1 chromatin dynamics, which resulted in the inhibition of proinflammatory pathway genes. The drug was well tolerated by mice and suppressed lipopolysaccharide- and tumor necrosis factor–α–mediated neutrophilic inflammation in the lungs. Science , this issue p. 834 ; see also p. 748 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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