The effects of hemoglobin glutamer-200 and iNO on pulmonary vascular tone and arterial oxygenation in an experimental acute respiratory distress syndrome
Autor: | Nora Jahn, Sven Bercker, Sven Laudi, Maria T. Voelker, Katharina Noreikat, Philipp Simon, Andreas Bergmann, Thilo Busch |
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Rok vydání: | 2018 |
Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty ARDS Mean arterial pressure Ventilation perfusion mismatch 030204 cardiovascular system & hematology Lung injury Nitric Oxide Hydroxyethyl Starch Derivatives Hemoglobins 03 medical and health sciences 0302 clinical medicine Blood Substitutes Internal medicine Hypoxic pulmonary vasoconstriction Administration Inhalation Ventricular Pressure medicine Animals Arterial Pressure Pharmacology (medical) 030212 general & internal medicine Rats Wistar Respiratory Distress Syndrome Pulmonary Gas Exchange business.industry Biochemistry (medical) medicine.disease Rats Oxygen Disease Models Animal medicine.anatomical_structure Vasoconstriction Vascular resistance Cardiology Arterial blood medicine.symptom business |
Zdroj: | Pulmonary Pharmacology & Therapeutics. 49:130-133 |
ISSN: | 1094-5539 |
DOI: | 10.1016/j.pupt.2018.01.009 |
Popis: | Introduction Hemoglobin-based oxygen carriers (HBOC) have been developed as an alternative to blood transfusions . Their nitric-oxide-scavenging properties HBOC also induce vasoconstriction . In acute lung injury , an excess of nitric oxide results in a general vasodilation , reducing oxygenation by impairing the hypoxic pulmonary vasoconstriction . Inhaled nitric oxide (iNO) is used to correct the ventilation perfusion mismatch . We hypothesized that the additional use of HBOC might increase this effect. In a rodent model of ARDS we evaluated the combined effect of HBOC and iNO on vascular tone and gas exchange. Methods ARDS was induced in anaesthetized Wistar rats by saline lavage and aggressive ventilation. Two groups received either hydroxyethylstarch 10% (HES; n = 10) or the HBOC hemoglobin glutamer-200 (HBOC-200; n = 10) via a central venous infusion . Additionally, both groups received iNO. Monitoring of the right ventricular pressure (RVP) and mean arterial pressure (MAP) was performed with microtip transducers. Arterial oxygenation was measured via arterial blood gas analyses. Results Application of HBOC-200 led to a significant increase of MAP and RVP when compared to baseline and to the HES group. This effect was reversed by iNO. The application of HBOC and iNO had no effect on the arterial oxygenation over time. No difference in arterial oxygenation was found between the groups. Conclusion Application of HBOC led to an increase of systemic and pulmonary vascular resistance in this animal model of ARDS. The increase in RVP was reversed by iNO. Pulmonary vasoconstriction by hemoglobin glutamer-200 in combination with iNO did not improve arterial oxygenation in ARDS. |
Databáze: | OpenAIRE |
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