Intracerebral haemorrhage-induced injury progression assessed by cross-sectional photoacoustic tomography
| Autor: | Max Jiang, Jinge Yang, Qiwen Xu, Yuan Zhao, Dan Wu, Guang Zhang, Xin Yang, Huabei Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
High resolution 01 natural sciences Article 010309 optics 03 medical and health sciences 0302 clinical medicine Hematoma Neuroimaging In vivo 0103 physical sciences medicine Medical physics cardiovascular diseases Multimodal imaging medicine.diagnostic_test business.industry medicine.disease Atomic and Molecular Physics and Optics Diffuse optical imaging nervous system diseases Positron emission tomography Photoacoustic tomography business Nuclear medicine 030217 neurology & neurosurgery Biotechnology |
| Popis: | In this study, we in vivo examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using cross-sectional photoacoustic tomography (csPAT). csPAT displayed high resolution with high sensitivity for ICH detection. The PAT images obtained showed high correlation with conventional histologic images. Quantitative analysis of the hematoma areas detected by csPAT showed high consistency with the neurologic deficit score (NDS). By utilizing the dual-wavelength method, the development of the hemoglobin area was monitored. Our results indicated that noninvasive csPAT can be used to track the dynamic progression of post-ICH, and to evaluate therapeutic interventions in preclinical ICH models. |
| Databáze: | OpenAIRE |
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