Preclinical evaluation of MnDPDP: new paramagnetic hepatobiliary contrast agent for MR imaging
| Autor: | Steven C. Quay, C J Fretz, G Elizondo, Joseph T. Ferrucci, Yuk-Ming Tsang, Dilip Worah, David D. Stark, Scott M. Rocklage, M C Chen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Biodistribution Gadolinium Drug Evaluation Preclinical Contrast Media chemistry.chemical_element Lethal Dose 50 Mice chemistry.chemical_compound Dogs Liver tissue Mangafodipir Animals Medicine DOTA Tissue Distribution Radiology Nuclear Medicine and imaging Edetic Acid Manganese medicine.diagnostic_test business.industry Manganese Poisoning Magnetic resonance imaging Magnetic Resonance Imaging Effective dose (pharmacology) Mr imaging Rats Liver chemistry Pyridoxal Phosphate Female business Nuclear medicine medicine.drug |
| Zdroj: | Radiology. 178:73-78 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.178.1.1898538 |
| Popis: | Manganese(II)-N,N'-dipyridoxylethylenediamine-N,N'-diacetate-5,5'-bis (phosphate) (MnDPDP) is a paramagnetic complex designed for use as a hepatobiliary agent. The T1 relaxivity of MnDPDP (2.8 [mmol/L]-1.sec-1 in aqueous solution) was similar to that of gadolinium diethylenetriaminepentaacetic acid (DTPA) (4.5 [mmol/L]-1.sec-1) and gadolinium tetraazocyclodecanetetraacetic acid (DOTA) (3.8 [mmol/L]-1.sec-1). However, in liver tissue the T1 relaxivity of MnDPDP (21.7 [mmol/L]-1.sec-1) was threefold higher than that reported for Gd-DOTA (6.7 [mmol/L]-1.sec-1). Maximum liver T1 relaxation enhancement occurred 30 minutes after injection of MnDPDP, at which time 54MnDPDP biodistribution studies indicated that 13% of total body activity was in the liver. Enhanced (MnDPDP, 50 mumol/kg) MR images showed a fivefold increase in tumor-liver contrast-to-noise ratio over baseline unenhanced images. Results of the authors' acute and subchronic toxicity studies suggest that MnDPDP will be safe at the doses necessary for clinical imaging; at 10 mumol/kg, the safety factor (LD50/effective dose) for MnDPDP is 540, significantly greater than the safety factor of Gd-DTPA (ie, 60-100). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|