Intrinsic Connectivity Identifies the Hippocampus as a Main Crossroad between Alzheimer's and Semantic Dementia-Targeted Networks.: Brain networks, hippocampus and memory in dementia
| Autor: | Francis Eustache, Renaud La Joie, Stéphanie Egret, Vincent de La Sayette, Audrey Perrotin, Béatrice Desgranges, Gaël Chételat, Brigitte Landeau, Alice Pélerin, Alexandre Bejanin, Serge Belliard, Florence Mézenge |
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| Přispěvatelé: | Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Rennes], CHU Pontchaillou [Rennes], Service de Neurologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), This work was supported by the Fondation Plan Alzheimer (Alzheimer Plan 2008- 2012), Programme Hospitalier de Recherche Clinique (PHRC National 2011), Région Basse Normandie, and Institut National de la Santé et de la Recherche Médicale (Inserm), including the École de l'Inserm-Liliane Bettencourt and Fondation Philippe Chatrier. |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
hippocampus Neuroscience(all) resting-state functional connectivity Hippocampus Semantic dementia Neuropsychological Tests default mode network Cognition Atrophy Alzheimer Disease Memory medicine Humans FDG-PET Episodic memory Default mode network Aged Aged 80 and over Brain Mapping General Neuroscience Neurodegeneration fMRI episodic memory Middle Aged Alzheimer's disease medicine.disease brain networks semantic dementia Frontotemporal Dementia Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Disconnection Nerve Net Psychology Neuroscience Cognitive psychology |
| Zdroj: | Neuron Neuron, Elsevier, 2014, 81 (6), pp.1417-28. ⟨10.1016/j.neuron.2014.01.026⟩ |
| ISSN: | 0896-6273 |
| Popis: | International audience; Alzheimer's disease (AD) and semantic dementia (SD) are both characterized by severe atrophy in the hippocampus, a brain region underlying episodic memory; paradoxically, episodic memory is relatively preserved in SD. Here, we used intrinsic connectivity analyses and showed that the brain networks differentially vulnerable to each disease converge to the hippocampus in the healthy brain. As neurodegeneration is thought to spread within preexisting networks, the common hippocampal atrophy in both diseases is likely due to its location at the crossroad between both vulnerable networks. Yet, we showed that in the normal brain, these networks harbor different functions, with episodic memory relying on the AD-vulnerable network only. Overall, disease-associated cognitive deficits seem to reflect the disruption of targeted networks more than atrophy in specific brain regions: in AD, over hippocampal atrophy, episodic memory deficits are likely due to disconnection within a memory-related network. |
| Databáze: | OpenAIRE |
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