International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels
| Autor: | Fen Huang, Xiuming Wong, Lily Yeh Jan |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Glycosylation
Protein Conformation Anoctamins Xenopus Proteins Pharmacology Biology law.invention Chloride Channels law Terminology as Topic Calcium-Activated Chloride Channels Animals Humans Phosphorylation Anoctamin-1 Clinical pharmacology International Agencies Smooth muscle contraction Transmembrane protein Electrophysiological Phenomena Neoplasm Proteins Cell biology IUPHAR Nomenclature Report Organ Specificity Chloride channel Molecular Medicine Function (biology) |
| Zdroj: | Pharmacological Reviews. 64:1-15 |
| ISSN: | 1521-0081 0031-6997 |
| DOI: | 10.1124/pr.111.005009 |
| Popis: | Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation. |
| Databáze: | OpenAIRE |
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