Anti-androgenic Activity of Myricae Cortex. Isolation of Active Constituents from Bark of Myrica rubra
| Autor: | Miho Yamazaki, Michinori Kubo, Yusuke Asanuma, Hideaki Matsuda, Keizo Matsuo |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
China medicine.medical_specialty Pharmaceutical Science Hamster Growth Pharmacognosy Plant Epidermis Rats Sprague-Dawley Myricaceae Mice chemistry.chemical_compound 5-alpha Reductase Inhibitors In vivo Cricetinae Internal medicine medicine Animals Enzyme Inhibitors Pharmacology Plants Medicinal Mesocricetus biology Traditional medicine Plant Extracts Androgen Antagonists Biological activity General Medicine biology.organism_classification Rats Mice Inbred C57BL Endocrinology chemistry visual_art visual_art.visual_art_medium Indicators and Reagents Bark Myricetin Orchiectomy Myrica rubra Hair |
| Zdroj: | Biological and Pharmaceutical Bulletin. 24:259-263 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.24.259 |
| Popis: | The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra Sieb. et Zucc., Myricaceae) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles. |
| Databáze: | OpenAIRE |
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