7T μMRI of mesenteric venous ischemia in a rat model: Timing of the appearance of findings
| Autor: | Roberto Di Mizio, Antonio Rotondo, Serena Russo, M. Corona, Nicola Landi, Carlo Cavaliere, Roberto Grassi, Francesca Iacobellis, Daniela Berritto, Francesco Somma |
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| Přispěvatelé: | Somma, F, Berritto, D, Iacobellis, F, Landi, N, Cavaliere, C, Corona, M, Russo, S, Dimizio, R, Rotondo, Antonio, Grassi, Roberto |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Rat model Group ii Biomedical Engineering Biophysics Ischemia Future application Sensitivity and Specificity Rats Sprague-Dawley Mesenteric Veins Image Interpretation Computer-Assisted medicine Animals Mesentery Radiology Nuclear Medicine and imaging Pathological Venous Thrombosis medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging medicine.disease Rats Mesenteric ischemia Models Animal Radiology Ligation business Magnetic Resonance Angiography |
| Zdroj: | Magnetic Resonance Imaging. 31:408-413 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/j.mri.2012.08.003 |
| Popis: | "OBJECTIVES: . . The aim of this study is to analyze the chronological development of macroscopic, microscopic and magnetic resonance imaging (MRI) findings in a rat model of Superior Mesenteric Venous (SMV) ligation, and to evaluate the role of MRI in the diagnosis of mesenteric venous thrombosis.. . METHODS: . . Thirty adult Sprague-Dawley rats were used and divided in two different groups that underwent a different surgical model and a different monitoring of ischemic damage. Group I underwent macroscopical and histological observation; Group II underwent 7T μMRI evaluation and histological analysis.. . RESULTS: . . The first alterations occurred 30 min after SMV ligation and progressively worsened until the eighth hour. The morphological and MRI findings showed the same course.. . CONCLUSIONS: . . This study provides a systematic evaluation of early anatomopathological and MRI findings following the SMV ligation. MRI allows to identify the early pathological findings of venous mesenteric ischemia and allows to correlate those to the histopathological features. Our data suggest a relevant role of MRI in the diagnostic management of mesenteric venous thrombosis, allowing to non-invasively identify and characterize the histopathologic findings. So, thanks to these skills, its future application in early diagnosis of human mesenteric venous ischemia is supposable.. " |
| Databáze: | OpenAIRE |
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