Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors
| Autor: | Magdalena Lebiedzinska-Arciszewska, Mariusz R. Wieckowski, Monika Prill, Wiesława Grajkowska, Paolo Pinton, Giampaolo Morciano, Michal Dabrowski, Agnieszka Karkucinska-Wieckowska, Agata Charzynska, Maciej Pronicki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gene isoform
ShcA Tropomyosin receptor kinase B Article Protein expression NO 03 medical and health sciences 0302 clinical medicine Medicine Oligodendroglial Tumor 030304 developmental biology 0303 health sciences business.industry TrkB General Medicine Pediatric brain tumors Malignancy grade Embryonal tumors Pediatric brain 030220 oncology & carcinogenesis Cancer research Choroid plexus Ras business |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 2219, p 2219 (2021) Journal of Clinical Medicine Volume 10 Issue 10 |
| Popis: | Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting different groups such as choroid plexus tumors, diffuse astrocytic and oligodendroglial tumors, embryonal tumors, ependymal tumors, and other astrocytic tumors as well as tumor malignancy grade, in order to characterize the expression profile of Ras, TrkB, and three isoforms of ShcA, namely, p66Shc, p52Shc, and p46Shc proteins. The main aim of our study was to evaluate the potential correlation between the type of pediatric brain tumors, tumor malignancy grade, and the expression patterns of the investigated proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|