α-Amylase inhibitory triterpene from Abrus precatorius leaves
| Autor: | Miyuki Shimada, Ryuta Yonemoto, Eisuke Kato, Jun Kawabata, Maria D.P.T. Gunawan-Puteri |
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| Rok vydání: | 2014 |
| Předmět: |
Ketone
Swine Mixed inhibition Pancreatic alpha-Amylases Inhibitory postsynaptic potential chemistry.chemical_compound Triterpene Abrus precatorius Animals Amylase Enzyme Inhibitors chemistry.chemical_classification biology Molecular Structure Plant Extracts General Chemistry biology.organism_classification Triterpenes Plant Leaves Kinetics Enzyme chemistry Biochemistry Abrus biology.protein General Agricultural and Biological Sciences Luteolin |
| Zdroj: | Journal of agricultural and food chemistry. 62(33) |
| ISSN: | 1520-5118 |
| Popis: | In the screening experiments for porcine pancreatic α-amylase inhibitors in 18 plants obtained from Indonesia, a potent inhibitory activity was detected in the extract of leaves of Abrus precatorius. The enzyme assay-guided fractionation of the extract led to the isolation of a triterpene ketone, lupenone (1), as a potent α-amylase inhibitor, together with 24-methylenecycloartenone (2) and luteolin (3). The mode of inhibition of compound 1 against porcine pancreatic α-amylase was a mixed inhibition. This is the first report that describes the potent α-amylase inhibitory activity of the low-polar triterpene ketone similar to compound 1. A comparison of the activities of the isolate and related compounds indicated the importance of C-3 ketone and the lupane skeleton in the α-amylase inhibitory activity. |
| Databáze: | OpenAIRE |
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