Efficient syntheses of novel C2'-alkylated (+/-)-K252a analogues

Autor:	Yumiko Hirokawa, John L. Wood, Thao Nheu, Hiroshi Maruta,‡,§ and, Hong S. He, Ryan D. White, J. Brad Shotwell, Kazuhiko Tamaki, Ioana Drutu, Dejah T. Petsch
Rok vydání:	2001
Předmět:	Alkylation Chemistry Stereochemistry Organic Chemistry Carbazoles Molecular Conformation Stereoisomerism Biochemistry Molecular conformation Indole Alkaloids Coupling (electronics) Indicators and Reagents Physical and Theoretical Chemistry Enzyme Inhibitors Protein Kinase C
Zdroj:	Organic letters. 3(11)
ISSN:	1523-7060
Popis:	Recent efforts in our laboratories have resulted in a synthetic approach toward C2‘-alkylated K252a analogues via extension of a K252a cyclofuranosylation strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybenzyl)-staurosporinone (21) with a number of highly functionalized carbohydrates has given access to previously unattainable, biologically relevant analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc3f0032d86a12707fc980d8ad69172 https://pubmed.ncbi.nlm.nih.gov/11405687 Zobrazit plný text záznamu