Maternal exposure to tributyltin during early gestation increases adverse pregnancy outcomes by impairing placental development
| Autor: | Siying Lu, Jun Zhu, Xin Shen, Bei Yang, Haibin Kuang, Wenyu Jiang, Hui Liu, Chuanzhen Yang, Yafen Ye, Mengling Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Health
Toxicology and Mutagenesis Placenta 010501 environmental sciences Management Monitoring Policy and Law Biology Toxicology medicine.disease_cause 01 natural sciences Andrology 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Pregnancy medicine Basic Helix-Loop-Helix Transcription Factors Animals Humans 0105 earth and related environmental sciences Fetus Pregnancy Outcome Embryo General Medicine medicine.disease Placentation medicine.anatomical_structure chemistry Maternal Exposure 030220 oncology & carcinogenesis Toxicity Tributyltin Gestation Female Trialkyltin Compounds Oxidative stress |
| Zdroj: | Environmental toxicologyREFERENCES. 36(7) |
| ISSN: | 1522-7278 |
| Popis: | Tributyltin (TBT) is a persistent organotin pollutant widely used as agricultural and wood biocides, exhibiting well-documented toxicity to reproductive functions in aquatic organisms. However, the effect of TBT on early pregnancy and placental development has been rarely studied in mice. Pregnant mice were fed with 0, 0.2, and 2 mg/kg/day TBT from gravid day 1 to day 8 or 13. TBT exposure led to an increase in the number of resorbed embryo and a reduction in the weight of fetus at gestational days 13. Further study showed that TBT significantly decreased placental weight and area, lowered laminin immunoreactivity and the expressions of placental development-related molecules including Fra1, Eomes, Hand1, and Ascl2. Moreover, TBT treatment markedly inhibited the placental proliferation and induced up-regulation of p53 and cleaved caspase-3 proteins, and down-regulation of Bcl-2 protein. In addition, TBT administration increased levels of malondialdehyde and H2 O2 and decreased activities of catalase and superoxide dismutase. Collectively, these results suggested TBT-induced adverse pregnancy outcomes during early pregnancy might be involved in developmental disorders of the placenta via dysregulation of key molecules, proliferation, apoptosis, and oxidative stress. |
| Databáze: | OpenAIRE |
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