Histological comparison of DBBM and platelet rich fibrin for guided bone regeneration in a rabbit model
| Autor: | Christian Saavedra, Andres Rezuc, Rodrigo Maass, Christian Nappe, Cristian Poblete |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Collagen membrane Connective tissue 030206 dentistry digestive system diseases Platelet-rich fibrin 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis medicine Rabbit model Bone formation Bone regeneration business General Dentistry Research Paper |
| Zdroj: | J Oral Biol Craniofac Res |
| ISSN: | 2212-4268 |
| DOI: | 10.1016/j.jobcr.2020.05.001 |
| Popis: | PURPOSE: To histologically evaluate the use of bovine derived deproteinized xenograft (DBBM), leukocyte and platelet rich fibrin (L-PRF) and the combination of both in Guided Bone Regeneration (GBR) performed in non-critical size defects in rabbit. METHODS: A prospective experimental study was performed. Four bone defects in the tibiae of 12 rabbits were made and each of them was filled with DBBM, L-PRF, a combination of DBBM + L-PRF or was left to heal as control site. All defects were covered with a collagen membrane. Rabbits were randomly distributed in three groups and euthanatized at 3, 6 or 9 weeks. Samples were obtained and histologically analyzed to determine vital bone, connective tissue and remaining graft particles percentage. Analysis of variance, Kruskal Wallis and non-paired t-test where used to evaluate the significance of the results. RESULTS: At 3 weeks of healing, DBBM showed significantly more vital bone percentage than L-PRF (p = 0,05) and DBBM + L-PRF showed significantly less connective tissue than control (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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