Midregional pro-atrial natriuretic peptide, an important member of the natriuretic peptide family: potential role in diagnosis and prognosis of cardiovascular disease
| Autor: | Marzenna Zielińska, Karolina Idzikowska |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Neurology medicine.drug_class heart failure Review Disease 030204 cardiovascular system & hematology Bioinformatics Biochemistry MR-proANP Natriuresis Pathogenesis 03 medical and health sciences R5-920 0302 clinical medicine cardiovascular disease medicine Natriuretic peptide Humans Obesity 030212 general & internal medicine Myocardial infarction Renal Insufficiency Chronic business.industry Biochemistry (medical) Cell Biology General Medicine Prognosis medicine.disease myocardial infarction Diabetes Mellitus Type 2 Cardiovascular Diseases Heart failure biomarker Biomarker (medicine) natriuretic peptides business Atrial Natriuretic Factor Biomarkers |
| Zdroj: | Journal of International Medical Research, Vol 46 (2018) The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060518786907 |
| Popis: | Midregional pro-atrial natriuretic peptide (MR-proANP), first isolated in 1981, is a novel peptide with multiple biological functions, especially within the cardiovascular system. This peptide plays an important role in many processes, including natriuresis, diuresis, and other physiological and pathophysiological pathways in the human body. Several electronic databases (PubMed, EBSCO, Scopus, and ScienceDirect) were analyzed in the present literature review. The aim of this study was to elucidate the wide roles of MR-proANP, which can be analyzed because of the development of a new sandwich immunoassay, and to determine the possible diagnostic and prognostic implications of MR-proANP on cardiovascular disease and other disorders. The studies discussed in this literature review provide valuable data on the role of ANP in the pathogenesis, diagnostic process, prognosis, and potential therapeutic strategies for disease. Although ANP is mainly associated with cardiovascular disease, it may be used as a biomarker in diabetology, neurology, and metabolic disorders. |
| Databáze: | OpenAIRE |
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