In vitro dissolution rates of six 8-methoxypsoralen formulations

Autor:	R. H. Cormane, L. M. L. Stolk, P. A. Van Zweiten, A. Pasman
Rok vydání:	1987
Předmět:	Time Factors Tissue concentrations Chromatography In vitro dissolution Drug Compounding Spectrophotometry Atomic Methoxsalen Capsule Capsules Dermatology Polyethylene glycol Pharmacology chemistry.chemical_compound Solubility chemistry medicine Dissolution Psoralen Tablets medicine.drug
Zdroj:	British Journal of Dermatology. 116:813-821
ISSN:	1365-2133 0007-0963
Popis:	SUMMARY Dissolution rates in water of six oral 8-methoxypsoralen formulations were determined with both the rotating basket method and a column type flow-through method. Comparable and reproducible results were obtained with both methods. In view of the necessity in psoralen UVA (PUVA) therapy that effective tissue concentrations of the drug be present in the skin during the irradiation period, we propose a requirement for a dissolution rate of 8-MOP tablets or capsules of at least 80% within 25 min. None of the three preparations registered in The Netherlands met this requirement. However, two preparations from abroad and a new capsule formulated in our pharmacy department with solid 8-MOP dispersed in polyethylene glycol 6000 showed satisfactory dissolution profiles.
Databáze:	OpenAIRE
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