Nutritional supplements in the management of oral mucositis in patients with head and neck cancer: Narrative literary review
| Autor: | Amanda de Sousa Melo, Manoela Carrera, Juliana Borges de Lima Dantas, Alena Ribeiro Alves Peixoto Medrado, Hayana Ramos Lima, Gabriela Botelho Martins |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Side effect Endocrinology Diabetes and Metabolism medicine.medical_treatment Psychological intervention 030209 endocrinology & metabolism Antineoplastic Agents Cochrane Library 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine medicine Mucositis Humans Stomatitis 030109 nutrition & dietetics Nutrition and Dietetics business.industry Vitamin E Head and neck cancer medicine.disease Glutamine Head and Neck Neoplasms Dietary Supplements Quality of Life business |
| Zdroj: | Clinical nutrition ESPEN. 43 |
| ISSN: | 2405-4577 |
| Popis: | Summary Background and aims Oral mucositis is the most common side effect in response to anticancer therapies in the head and neck region. It has a debilitating potential for the health of affected individuals, negatively interfering with nutritional status and quality of life. Due to the great complexity of its pathogenicity, different forms of interventions for prevention and treatment are being studied, including nutritional supplements with vitamin E, zinc and glutamine. This study aimed to review the literature on the influence of nutrients, in supplement form, for prevention and/or treatment of mucositis in patients with head and neck cancer. Methods A survey of studies related to the definition, treatment and prevention of mucositis with nutrients was carried out between January 2018 and July 2019, using the Pubmed, Cochrane Library and Scielo databases. In the end, 61 relevant scientific publications were selected between the years 2004 and 2019. Results Nutrients such as vitamin E, glutamine and zinc are forms of supplementation that have positive effects on the manifestation and severity of oral mucositis due to their antioxidant and immunomodulatory properties. However, some studies reveal that antioxidant properties may reduce the effectiveness of antineoplastic therapy. Conclusions This study suggests the effectiveness of vitamin E, zinc and glutamine in preventing and treating oral mucositis. However, the importance of new clinical researches to clarify possible doubts is highlighted, as well as the creation of a protocol that includes the dose, route and time of administration, for greater safety in use. |
| Databáze: | OpenAIRE |
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