Kikuchi-Fujimoto's disease: report of familial occurrence in two human leucocyte antigen-identical non-twin sisters
| Autor: | Samir S. Amr, A R A Amir, Salwa S. Sheikh |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Leukopenia business.industry Forme fruste Disease Human leukocyte antigen medicine.disease Connective tissue disease Nuclear Family Phenotype HLA Antigens Cervical lymphadenopathy Immunology Internal Medicine Genetic predisposition Etiology Humans Medicine Female medicine.symptom business Histiocytic Necrotizing Lymphadenitis |
| Zdroj: | Journal of Internal Medicine. 252:79-83 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1046/j.1365-2796.2002.01004.x |
| Popis: | Kikuchi-Fujimoto's disease (KFD) is a self-limiting condition usually presenting as cervical lymphadenopathy, with fever and leukopenia, in young adult females. No specific aetiology has been identified yet, although some authors believe that KFD is a 'forme fruste' of systemic lupus erythematosus. Certain human leucocyte antigen (HLA) types have also been associated with KFD. We herein report KFD in two non-twin sisters with HLA-identical phenotype, who presented 10 years apart. Neither patient had evidence of recent infection or connective tissue disease. The familial occurrence emphasizes the possibility of genetic predisposition and calls for a more extensive search for a specific cause of KFD. |
| Databáze: | OpenAIRE |
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