Relation between HBsAg Binding with Polymerized Human Serum Albumin and HBV Replication
| Autor: | Tandon Bn, Subrat K. Acharya, Gandhi Bm, Mohammad Irshad |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Hepatitis B virus
HBsAg DNA polymerase Serum albumin Enzyme-Linked Immunosorbent Assay Serum Albumin Human DNA-Directed DNA Polymerase Virus Replication medicine.disease_cause Virus Virology medicine Humans Hepatitis B e Antigens Serum Albumin Hepatitis B Surface Antigens biology Chemistry virus diseases Hepatitis B medicine.disease biology.organism_classification Human serum albumin Molecular biology digestive system diseases Infectious Diseases Hepadnaviridae Carrier State biology.protein medicine.drug |
| Zdroj: | Intervirology. 27:91-94 |
| ISSN: | 1423-0100 0300-5526 |
| DOI: | 10.1159/000149725 |
| Popis: | The binding between hepatitis B surface antigen (HBsAg) and polymerized human serum albumin (poly-HSA) was studied in HBsAg-negative (25) and HBsAg-positive (92) sera by a sensitive enzyme-linked immunosorbent assay technique, and a correlation of binding activity was made with HBe-markers and hepatitis B virus-specific DNA polymerase. The binding could be detected only in HBsAg-positive sera and was found to be independent of the presence of HBe-markers and DNA polymerase activity. Further, binding was noted in significantly higher proportions of sera samples from the patient group compared with the healthy carrier group (p less than 0.01). |
| Databáze: | OpenAIRE |
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