Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

Autor: and Kenneth Mautner, Kentaro Onishi, Peter A.M. Everts, José Fábio Lana, Prathap Jayaram
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
lymphocytes
Aging
Angiogenesis
Review
Osteoarthritis
Pharmacology
Adaptive Immunity
immunomodulation
Bioinformatics
Regenerative medicine
lcsh:Chemistry
angiogenesis
0302 clinical medicine
neutrophils
lcsh:QH301-705.5
Cellular Senescence
Spectroscopy
Analgesics
Anti-Inflammatory Agents
Non-Steroidal
General Medicine
Computer Science Applications
Animal studies
medicine.symptom
monocytes
Serotonin
regenerative medicine
Inflammation
Platelet Transfusion
In Vitro Techniques
platelet dosing
Catalysis
rehabilitation
Unmet needs
Inorganic Chemistry
03 medical and health sciences
Terminology as Topic
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
business.industry
allergology
Organic Chemistry
platelet-rich plasma
medicine.disease
Immunity
Innate
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
inflammation
analgesic effects
Platelet-rich plasma
Angiogenesis Inducing Agents
business
Wound healing
030217 neurology & neurosurgery
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 7794, p 7794 (2020)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
DOI: 10.0069/v1
Popis: Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols.
Databáze: OpenAIRE
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