Improved Protocol for the Synthesis of Flexibly Protected Morpholino Monomers from Unprotected Ribonucleosides

Autor:	Bappaditya Nandi, Surajit Sinha, Sankha Pattanayak, Sibasish Paul
Rok vydání:	2012
Předmět:	Molecular Structure Morpholino Chemistry General Medicine Biochemistry Reductive amination Morpholinos chemistry.chemical_compound Monomer Present method Genetics Molecular Medicine Organic chemistry Amine gas treating Antisense Agents Ribonucleosides Glycol cleavage
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 31:763-782
ISSN:	1532-2335 1525-7770
DOI:	10.1080/15257770.2012.724491
Popis:	An inexpensive and much improved protocol has been developed for the synthesis of protected morpholino monomers from unprotected ribonucleosides in high overall yield, using oxidative glycol cleavage and reductive amination strategy. Unlike the previous methods, the present strategy allows installing the exocyclic amine protections at a later stage, and thus avoids the use of expensive, or commercially unavailable, exocyclic amine-protected ribonucleosides as starting materials. To demonstrate the flexibility of the present method in choosing protecting groups, the monomers have been protected with several such groups of different deblocking properties at the exocyclic amine position.
Databáze:	OpenAIRE
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