Circulating miR-127-3p as a Potential Biomarker for Differential Diagnosis in Frontotemporal Dementia

Autor: Michela A. Denti, Margherita Grasso, Rosa Campopiano, Paola Piscopo, Giuseppe Bruno, Marina Gasparini, Giuseppina Talarico, Emanuela D'Acunto, Maria Puopolo, Stefano Gambardella, Anna Elisa Castellano, Alessio Crestini, Annamaria Confaloni
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Central nervous system
Disease
Sensitivity and Specificity
frontotemporal dementia
Diagnosis
Differential
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Internal medicine
mental disorders
microRNA
differential diagnosis
Humans
Medicine
Circulating MicroRNA
Biomarker
miR-127-3p
miRNA
Aged
Neuroscience (all)
Receiver operating characteristic
business.industry
General Neuroscience
General Medicine
medicine.disease
MicroRNAs
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
medicine.anatomical_structure
Psychiatry and Mental Health
Frontotemporal Dementia
Potential biomarkers
Biomarker (medicine)
Female
Geriatrics and Gerontology
Differential diagnosis
business
Frontotemporal dementia
MiRNA
Biomarkers
030217 neurology & neurosurgery
Popis: Given the heterogeneous nature of frontotemporal dementia (FTD), sensitive biomarkers are greatly needed for the accurate diagnosis of this neurodegenerative disorder. Circulating miRNAs have been reported as promising biomarkers for neurodegenerative disorders and processes affecting the central nervous system, especially in aging. The objective of the study was to evaluate if some circulating miRNAs linked with apoptosis (miR-29b-3p, miR-34a-5p, miR-16-5p, miR-17-5p, miR-107, miR-19b-3p, let-7b-5p, miR-26b-5p, and 127-3p) were able to distinguish between FTD patients and healthy controls. For this study, we enrolled 127 subjects, including 54 patients with FTD, 20 patients with Alzheimer's disease (AD), and 53 healthy controls. The qRT-PCR analysis showed a downregulation of miR-127-3p in FTD compared to controls, while the levels of other miRNAs remained unchanged. Then, miR-127-3p expression was also analyzed in AD patients, finding a different expression between two patient groups. A receiver operating characteristic curve was then created for miR-127-3p to discriminate FTD versus AD (AUC: 0.8986), and versus healthy controls (AUC: 0.8057). In conclusion, miR-127-3p could help to diagnose FTD and to distinguish it from AD.
Databáze: OpenAIRE
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