Lindenane sesquiterpenoid dimers from Chloranthus japonicus inhibit HIV-1 and HCV replication
| Autor: | Hai-Yang Liu, Li He, Xu-Jie Qin, Zhong-Quan Zhang, Ying Guo, Ming Yu Ba, Jia-Mei Guo, Haan Yan, Xu-Hong Li |
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| Rok vydání: | 2016 |
| Předmět: |
Anti hiv 1
Stereochemistry Chloranthus japonicus Human immunodeficiency virus (HIV) Hepacivirus Biology medicine.disease_cause Virus Replication 01 natural sciences Antiviral Agents Magnoliopsida Drug Discovery medicine Potency Humans Pharmacology Molecular Structure 010405 organic chemistry Anti hiv Wild type virus diseases General Medicine biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry HEK293 Cells Phytochemical HIV-1 Sesquiterpenes Chloranthaceae |
| Zdroj: | Fitoterapia. 115 |
| ISSN: | 1873-6971 |
| Popis: | Phytochemical investigation on the whole plant of Chloranthus japonicus (Chloranthaceae) led to the isolation and identification of three new lindenane-type sesquiterpenoid dimers, chlorajaponilides F–H ( 1 – 3 ), along with seven known ones ( 4 – 10 ). Their chemical structures were established by extensive spectral evidence. Compounds 1 and 2 are both dimeric sesquiterpenoids featuring a rare hydroperoxy group at C-5. All compounds were tested for their activities on wild type HIV-1 replication and compounds 1 , 2 , 5 , and 9 were effective with EC 50 values from 3.08 to 17.16 μM. All these four compounds showed the same inhibitory effects on the two NNRTI-resistant HIV strains as on wild-type HIV-1 with EC 50 change folds from 0.61 to 1.6 μM. Furthermore, compounds 1 , 5 , and 9 exhibited inhibitory activities on HCV replication with the similar potency as their activities on HIV-1. Our finding may provide a clue to address the problem of HIV-1 and HCV co-infection. |
| Databáze: | OpenAIRE |
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