General hospital outbreak of invasive candidiasis due to azole-resistant Candida parapsilosis associated with an Erg11 Y132F mutation
| Autor: | Mark Peacock, Dora E Corzo-Leon, Patricia Rodriguez-Zulueta, Grace J Salazar-Tamayo, Donna M. MacCallum |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Azoles Male 0301 basic medicine Antifungal Agents Candida parapsilosis 030106 microbiology Microbial Sensitivity Tests Hospitals General Disease cluster Disease Outbreaks Microbiology Fungal Proteins 03 medical and health sciences Drug Resistance Fungal medicine Humans Candidiasis Invasive Typing Mexico Retrospective Studies chemistry.chemical_classification biology Point mutation Outbreak General Medicine Middle Aged biology.organism_classification 030104 developmental biology Infectious Diseases Amino Acid Substitution chemistry Mutation Azole Microsatellite Female Original Article Fluconazole medicine.drug |
| Zdroj: | Med Mycol |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1093/mmy/myaa098 |
| Popis: | An increasing number of outbreaks due to resistant non-albicans Candida species have been reported worldwide. Between 2014 and 2016, Candida isolates causing invasive candidiasis were recovered in a Mexican hospital. Isolates were identified to species level and antifungal susceptibility was determined. In the time period studied, 74 invasive candidiasis cases were identified, with 38% (28/74) caused by Candida parapsilosis, out of which 54% (15/28) were fluconazole resistant. The ERG11 gene was sequenced for 12 recoverable fluconazole-resistant C. parapsilosis isolates and SNPs identified. The 12 isolates had one common silent point mutation in ERG11 (T591C) and seven isolates had an additional (A395T) mutation, which corresponded to Y132F. Four of the isolates carrying this mutation were closely related within the same cluster by microsatellite typing. This is the first report of an invasive candidiasis outbreak in Mexico due to azole-resistant C. parapsilosis associated with the Y132F substitution. |
| Databáze: | OpenAIRE |
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